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一个基于水和连续流量的可用级联:四醇化异环的可持续合成

Yaxi Wang¹, Suxian Fu¹, Deshu Kong¹

¹School of Materials Science & Engineering, Beijing Institute of Technology, Beijing 100081, China.

|November 28, 2025

概括

研究人员开发了一种绿色的,以水为基础的级联反应,以合成新的能量材料,如6-amino-7,8-dihydrotetrazolo-[5,1-f]-[1,2,4]-triazin-8-ol (AHTO). 这种更安全,更有效的方法加速了先进的能量化合物的开发.

科学领域:

能量材料化学能量材料化学
绿色化学绿色化学
过程化学过程化学

背景情况:

能源材料的创新往往受到成本和安全问题的限制.
级联反应提供了一个潜在的解决方案来克服这些局限性,使得更安全,更可扩展的合成.
开发新的富含的化合物对于下一代能量材料至关重要.

研究的目的:

开发一种新,安全和高效的合成能量材料的方法.
为了利用水基级联反应与流化学集成.
合成和描述一种新的富含的能量化合物,6-amino-7,8-dihydrotetrazolo-[5,1-f]-[1,2,4]-triazin-8-ol (AHTO) 和其衍生物.

主要方法:

采用以水为基础的级联反应策略来合成AHTO.
集成微通道连续流技术,以提高安全性和效率.
进行了亚胺基衍生物化,制备了6-亚胺基-7,8-二二四醇-[5,1-f]-[1,2,4]-triazin-8-ol (NHTO).

主要成果:

通过使用绿色水基级联反应成功合成AHTO,避免中间体隔离并将危险试剂降到最低.
在3小时的流量反应中,为AHTO获得了90.8%的结晶产量和98.1%的HPLC纯度.
准备的NHTO是一种潜在的新型无金属初级爆炸物.

结论:

在以水为基础的介质中整合布和流化学,在合成能量材料方面取得了重大进展.
这种方法提高了能源材料开发中的经济效率,安全性和环境可持续性.
开发的方法加速了新能源化合物的发现和生产,如AHTO和NHTO.

关键词:

连续流的连续流.能量材料是能量材料.绿色化学是一种绿色化学.异循环的不同循环.基于水的级联布.

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