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功能下降和带斑块进展之间的双向关联:在预测,预防和个性化医学的背景下进行纵向队列研究

Jinqi Wang¹, Xiaoyu Zhao¹, Rui Jin¹

¹Beijing Key Laboratory of Environment and Aging, Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China.

The EPMA journal

|November 28, 2025

概括

功能下降和动脉斑块的进展具有显著的双向关系. 监测估计的膜过率 (eGFR) 和总斑块面积 (TPA) 可以帮助预测心风险并指导个性化预防.

科学领域:

心血管疾病的研究研究.
腎臟病學 (nephrology) 是一種醫學專業.
血管生物学血管生物学

背景情况:

动脉样硬化和慢性病 (CKD) 是导致心血管疾病 (CVD) 和死亡的主要原因.
随着时间的推移,脏功能下降和动脉斑块 (CP) 进展之间的相互作用尚未得到充分理解.

研究的目的:

调查功能下降和CP进展之间的双向关联.
为了利用基线和重复测量估计的膜过率 (eGFR) 和总斑块面积 (TPA).
为预测性,预防性和个性化医疗 (PPPM/3PM) 策略提供信息.

主要方法:

来自北京健康管理队列的三个子队列的分析 (n=11,657至7,601).
交叉滞后的小组分析,以评估eGFR和TPA之间的双向关联.
考克斯的比例危害模型用于评估eGFR和TPA指标与发生的CP和功能下降的关联.

主要成果:

在eGFR和TPA之间发现了显著的双向关联.
较低的后续TPA是由更高的基线eGFR预测的,较低的后续eGFR是由更高的基线TPA预测的.
无论是eGFR斜率还是累积eGFR都与发生的CP负相关;TPA斜率和累积TPA都与功能下降有关.

结论:

功能下降和CP进展之间存在相互关系.
综合监测eGFR和TPA提供了早期心风险分层的潜力.
调查结果支持PPPM/3PM框架内的个性化预防策略.

关键词:

动脉样硬化是一种动脉样硬化.双向协会是一个双向协会.心血管疾病是什么心血管疾病冠状动脉斑块的形成群组研究是一项群组研究.交叉差距的小组分析.早期风险分层的早期分层.改善了心脏和脏结局.功能下降功能下降预测性预防性个性化医学 (PPPM/3PM)

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