预测,预防和个性化医学的多变量数据驱动框架,用于新发性阻塞性睡眠呼吸暂停患者的长期心房风险
Jian Zhu1, Yijun Wang2, Shoupeng Duan3
1Department of Cardiology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, 230000 Anhui China.
The EPMA journal
|November 28, 2025
概括
这项研究开发了一种XGBoost模型,用于预测阻塞性睡眠呼吸暂停 (OSA) 患者的心房动 (AF) 风险,提供个性化医学见解. 该模型实现了高精度,有助于早期风险评估和管理.
科学领域:
- 心脏病学和睡眠医学
- 预测分析和个性化医疗
背景情况:
- 在患有阻塞性睡眠呼吸暂停 (OSA) 的患者中,心房动 (AF) 构成了重大挑战.
- 传统的风险因素往往无法准确预测这个人群中的个人AF风险.
- 这项研究解决了OSA患者个性化风险预测的需求,特别是患有糖尿病的患者.
研究的目的:
- 开发和验证患有糖尿病和阻塞性睡眠呼吸暂停 (OSA) 的患者中心房动 (AF) 风险的预测性名录.
- 以预测,预防和个性化医学 (PPPM / 3PM) 在心血管风险分层中的应用为例.
主要方法:
- 进行了797名新发性OSA没有AF的患者的队列研究.
- 分析了53个基线临床特征,使用Boruta算法进行预先查.
- 选择XGBoost机器学习模型是因为其卓越的性能,使用AUC,校准曲线和DCA进行验证,并使用SHAP进行解释.
主要成果:
- 在独立验证队列中,XGBoost模型实现了0.922的AUC.
- 确定的主要预测因素包括年龄,禁食血糖,脂质样本,甘油三-葡萄糖指数,ANS指标,AHI和平均SPO2.
- SHAP分析证实了个别变量对长期AF风险的重大贡献.
结论:
- 一个基于XGBoost的PPPM/3PM框架显示出在预测新发性OSA患者长期AF风险方面卓越的临床性能.
- 开发的模型提供了个性化的风险评估方法,改善了临床决策.
相关概念视频
Sleep Apnea
452
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
452
Coronary Artery Disease IV: Preventive Measures
575
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
575
Asthma-IV: Diagnostic and Management
3.0K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.0K
Substance Use Disorders Affecting Sleep
369
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
369
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
3.1K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
3.1K
Combination Therapies and Personalized Medicine
5.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.9K


