相关实验视频

Updated: Jan 10, 2026

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells

Published on: February 14, 2025

在CD30阳性恶性淋巴瘤中,为增强采用免疫疗法而设计和功能化的NK细胞

Fang Tan¹, Rui Wei¹, Jiqing Su²

¹Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.

Molecular therapy. Nucleic acids

|November 28, 2025

概括

研究人员通过使用aptamers对自然杀手 (NK) 细胞进行了工程设计,以准CD30阳性淋巴瘤. 这种新的方法提高了NK细胞治疗对淋巴瘤的疗效,为目前的治疗提供了有希望的替代方案.

科学领域:

免疫治疗是一种免疫疗法.
分子生物学分子生物学
在瘤学瘤学.

背景情况:

采用细胞疗法,特别是仿真抗原受体 (CAR) -NK细胞,对血液性恶性瘤有望.
与CAR-T细胞相比,CAR-NK细胞具有优势,可以避免细胞因子释放综合征和移植与宿主疾病.
对于CAR-NK细胞治疗仍然存在挑战,包括操作复杂性,成本和安全问题.

研究的目的:

通过使用aptamer,设计具有瘤特异性向能力的NK细胞.
增强NK细胞对CD30阳性淋巴瘤的治疗疗效.
探索一种新的aptamer引导NK细胞战略,用于临床应用.

主要方法:

设计了一种多价值的阿帕特马 oligonucleotide 复合物与CD30的阿帕特马.
功能化的NK细胞与aptamer复合物使用点击化学.
评估了工程NK细胞的结合特异性和抗瘤作用in vitro和in vivo.

主要成果:

工程NK细胞专门与CD30阳性淋巴瘤细胞结合.
与父母NK细胞相比,Aptamer引导的NK细胞表现出增强的抗瘤活性.
该方法在体外和体外模型中显示出显著的治疗潜力.

结论:

发达的体功能化的NK细胞为CD30阳性淋巴瘤提供了特定的向.
这一策略提高了对恶性淋巴瘤的采用NK细胞治疗效率.
这种方法在淋巴瘤治疗中具有很大的临床转化潜力.

关键词:

有CD30阳性的淋巴瘤.在DNA结构中,DNA结构是DNA的结构.MT:寡核酸:治疗方法和应用.在 NK 细胞中,NK 细胞是 NK 细胞.采用细胞疗法采用细胞疗法它们是Aptamers.

更多相关视频

Flow Cytometry-based Assay for the Monitoring of NK Cell Functions

Flow Cytometry-based Assay for the Monitoring of NK Cell Functions

Published on: October 30, 2016

Natural Killer NK and CAR-NK Cell Expansion Method using Membrane Bound-IL-21-Modified B Cell Line

Natural Killer NK and CAR-NK Cell Expansion Method using Membrane Bound-IL-21-Modified B Cell Line

Published on: February 8, 2022

相关概念视频

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...