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电子烟使用者的炎症和致癌生物标志物签名:对约24,000名成年人的综合元分析

Khalid A Bin Abdulrahman¹, Amro K Bin Abdulrahman², Razique Anwer³

¹Department of Medical Education, College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.

International journal of public health

|November 28, 2025

概括

电子烟使用与炎症和潜在的癌症生物标志物有关. 虽然一些标记物比吸烟者低,但需要进一步的研究来确认风险.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
暴露的生物标志物

背景情况:

电子烟 (e-cig) 的使用普遍存在,引发了人们对潜在健康影响的担忧.
了解电子烟使用与生理反应之间的关联对于公共卫生至关重要.

研究的目的:

进行一项元分析,研究电子烟使用与肺炎和致癌的生物标志物之间的联系.
为了比较电子烟使用者,吸烟者和非吸烟者的生物标志物水平.

主要方法:

对多个数据库 (PubMed,Scopus等) 的系统审查. 从2014年开始到2024年4月.
包括16项研究,涉及24,079名成年人,分析生物样本中的生物标志物 (cotinine,NNAL,interleukins).
使用ANOVA和Tukey测试进行统计分析;通过GRADE评估证据确定性.

主要成果:

电子烟使用者的唾液中丁胺含量高于非吸烟者.
吸烟者显示NNAL水平显著升高.
与非吸烟者相比,电子烟使用者表现出炎症标志物 (IL-6,TNF-α) 的增加,但低于吸烟者.
在电子烟使用者中检测到的致癌生物标志物度低于吸烟者.

结论:

电子烟使用与改变的生物标志物有关,这些生物标志物表明炎症和潜在的致癌性.
这些效果部分反映了传统吸烟的效果.
需要进一步的纵向研究来确定因果关系和长期健康风险.

关键词:

这是一个元分析.致癌生物标志物致癌生物标志物电子烟 (e-cig) 是一种电子烟.电子烟电子烟是一种电子烟.肺癌是一种肺癌.肺炎肺炎肺炎肺炎烟草吸烟者烟草吸烟者

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