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视网膜质细胞的损失与多式视觉功能障碍有关,这种视觉功能障碍是由于光神经炎引起的

Mustafa Subhi^1,2, Sargis Manukyan^1,2,3, Gabriela Zabala^1,2

¹Visual Outcomes Laboratory, Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Multiple sclerosis journal - experimental, translational and clinical

|November 28, 2025

概括

结节细胞内状层 (GCIPL) 厚度的眼间差异有效地识别光神经炎 (ON) 后的视力问题. 这些GCIPL值可以更准确地评估多发性硬化症和相关疾病中的视觉功能障碍.

科学领域:

眼科医生眼科眼科
神经科学是一个神经科学.
医疗成像医学成像

背景情况:

视神经炎 (ON) 是多发性硬化和相关疾病 (MSRD) 的关键表现,导致视网膜神经退行,如质细胞内状层 (GCIPL) 稀薄.
眼间差异 (IED) 对于评估ON效应至关重要,考虑到个体基线变化.

研究的目的:

建立视网膜层眼睛间差异 (IED) 的值,这些差异与单边脱髓化视神经炎 (ON) 后的多式视觉功能障碍相关.

主要方法:

一项涉及MSRD参与者 (有和没有ON病史) 和健康对照者的横截面研究.
利用光学连贯断层扫描 (OCT),最佳校正视敏度,低对比度字母敏度 (LCLA),标准自动周边测量和彩色视觉测试.

主要成果:

特定的GCIPL IED值与视觉功能障碍有显著的关联:异色的6.5%,LCLA的1.25%,LCLA的11%,LCLA的2.5%,LCLA的13%,视野平均深度 (VFMD) 的15%,最小分辨率角对数 (logMAR) 的27%.
这些GCIPL IED关联与其他视网膜层IED相比,显示出更高的稳定性.

结论:

质细胞内状层 (GCIPL) 眼间差异 (IED) 值提供了多模式视觉功能障碍后视神经炎 (ON) 的更精确的反映.
这突显了GCIPL IED测量的临床实用性,用于管理MSRD患者.

关键词:

多发性硬化症是多发性硬化症.颜色视觉颜色视觉视觉颜色视觉团结体内形细胞层 - 团结体内形细胞层.视神经炎是一种视神经炎.光学连贯性断层扫描 (optical coherence tomography) 是一种光学连贯性断层扫描技术.视力敏度视力敏度视力敏度视野视野视野视野视野

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