关于认知障碍和痴呆症的疫苗研究:一个文献计量分析和未来展望 (2000-2025年)
Zhongli Wang1,2, Xiaojia Xue3, Hua Zhang3
1Centre for Health Management and Policy Research, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
Frontiers in neurology
|November 28, 2025
概括
针对认知障碍 (CI) 和痴呆症的疫苗研究正在迅速推进,转向预防和多学科方法. 未来的工作重点是针对多种途径的新型疫苗,克服与衰老相关的免疫衰退,以保护人口一级的痴呆症.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 疫苗研究正在从抗感染应用演变为治疗和预防认知障碍 (CI) 和痴呆症的治疗和预防策略.
- 将疫苗与神经退行症联系在一起的科学景观尚未被系统地绘制.
研究的目的:
- 系统地绘制与CI和痴呆相关的疫苗研究知识领域.
- 分析出版趋势,合作,关键研究人员和该领域的主题演变.
主要方法:
- 对来自Web of Science和PubMed (2000-2025) 的1395篇英语文章和评论进行了图书统计分析.
- 使用诸如VOSviewer,CiteSpace,Scimago Graphica和Charticulator等工具进行数据分析.
- 检查了出版物输出,协作网络,有影响力的期刊,关键字演变和共同引用集群.
主要成果:
- 年度出版物增加了近10倍,在2022年达到顶峰,美国领先于产出和协作.
- 确定了关键的研究集群和有影响力的作者,并注意到多元化,中国和欧洲最近的贡献.
- 专题分析显示,从粉样β疫苗转向被动免疫疗法,生物标志物引导翻译,多价值疫苗工程和免疫发生,人们对先天免疫和感染介导的神经炎症越来越感兴趣.
结论:
- 针对CI/痴呆症的疫苗研究是一个成熟的,专注于预防的多学科领域.
- 未来的方向包括开发针对粉样蛋白,蛋白和炎症的多表位或mRNA疫苗,以及加强老年人群免疫反应的策略.
- 将免疫学见解转化为有效的,人口层面的痴呆症预防策略是关键优先事项.
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