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与自闭症谱系障碍相关的变体在WAVE监管综合体中的共同特征

Song Xie1,2, Ke Zuo1,3,4, Silvia De Rubeis5,6,7,8,9,10

  • 1Computational Biomedicine, Institute of Neuroscience and Medicine INM-9, Forschungszentrum Jülich GmbH, Jülich, Germany.

Frontiers in computational neuroscience
|November 28, 2025
PubMed
概括

自闭症谱系障碍 (ASD) 变体破坏了WAVE调控复合体 (WRC),影响了行为动态. 分子动力学模拟显示突变削弱了WRC相互作用,可能导致ASD病原体的异常激活和功能障碍.

关键词:
波浪监管综合体 波浪监管综合体全osteric 分析 的分析.自闭症谱系障碍 自闭症谱系障碍错误的意义变体的变体分子动力学分子动力学神经发育障碍是一种神经发育障碍.

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