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体重指数调解红细胞分布宽度与血清白蛋白指数和结石风险之间的关联:基于人口的研究
Yuwen Zhong1, Ganglin Kang1, Jing He2
1Department of Pathology, Luzhou Maternal and Child Health Hospital (Luzhou Second People's Hospital), Luzhou, China.
Therapeutic advances in urology
|November 28, 2025
概括
红细胞分布宽度与血清白蛋白 (RAR) 指数的比率与较高的结石风险有关. 身体质量指数 (BMI) 调解了这种关系,特别是在肥胖个体中.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 临床生物化学 临床生物化学
- 流行病学 流行病学
背景情况:
- 结石疾病影响了美国人口的很大一部分.
- 红细胞分布宽度与血清白蛋白 (RAR) 指数的比率是一个新兴的生物标志物.
- 了解结石的风险因素和媒介对于公共卫生至关重要.
研究的目的:
- 调查RAR指数与美国结石患病率之间的关联.
- 检查身体质量指数 (BMI) 在这种关系中的调解作用.
- 为预防和管理结石提供见解.
主要方法:
- 使用NHANES数据 (2009-2018) 的横截面研究,共有20755名参与者.
- 使用多重逻辑回归,子组分析和调解分析.
- 非线性剂量反应关系使用曲线拟合和线条方法进行评估.
主要成果:
- 在RAR指数和结石患病率 (OR: 1.37) 之间发现了显著的正相关性.
- 确定了一种非线性,S型的剂量反应关系.
- 身体质量指数 (BMI) 中介于RAR指数和结石之间的联系的24.5%.
- 这种联系在肥胖个体中更为明显.
结论:
- RAR指数与结石的患病率增加有非线性关联.
- 体重指数 (BMI) 在RAR指数-结石关系中起着重要的调解作用.
- 肥胖个体,特别是特定的种族群体,显示RAR指数对结石风险的影响更明显.
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