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肝炎病毒pgRNA在纤维化和HCC倾向中是否有任何作用?

Aikaterini Skeva¹, Theocharis Konstantinidis¹, Vasileios Papadopoulos²

¹Laboratory of Microbiology, Department of Medicine, Faculty of Health Sciences, Democritus University of Thrace, Alexandroupolis, Greece.

Frontiers in medicine

|November 28, 2025

概括

发现B型肝炎病毒前基因组RNA (pgRNA) 与肝硬化相关,但与治疗患者的FIB-4或PAGE-B等常见疾病得分无关. 需要进一步的研究来确定pgRNA对肝纤维化和肝细胞癌风险的预后价值.

科学领域:

肝病学肝病学是一种肝病学.
病毒学病毒学
生物化学生物化学

背景情况:

慢性乙型肝炎 (CHB) 感染需要长期的抗病毒治疗.
监测治疗疗效和疾病进展对于管理CHB至关重要.
需要新的生物标志物来更好地预测肝纤维化和肝细胞癌 (HCC) 风险.

研究的目的:

研究B型肝炎病毒前基因组RNA (pgRNA) 在HBeAg阴性CHB患者的核酸/核酸类比 (NA) 治疗期间的作用.
为了比较pgRNA与已确定的疾病严重程度得分的相关性,即FIB-4和PAGE-B.
评估pgRNA作为肝纤维化和HCC发展的预后标记物的潜力.

主要方法:

分析了长期接受NA治疗的88名HBeAg阴性CHB患者.
使用PCR和RT-PCR对乙型肝炎表面抗原 (HBsAg),HBV DNA和病毒RNA (核心前RNA和pgRNA) 的量化.
计算FIB-4和PAGE-B分数,分别用于肝硬化和HCC预后.
使用R工作室和SPSS进行多变量统计分析.

主要成果:

18.1%的患者检测出HBV pgRNA阳性,显示出与肝硬化有正相关性,与治疗持续时间有潜在的负相关性.
在对多种临床和病毒学因素进行调整后,HBV pgRNA与FIB-4或PAGE-B得分没有独立相关.
顺序回归分析表明FIB-4和PAGE-B的显著模型 (p < 10^-12),但pgRNA没有成为独立的预测因素.

结论:

虽然HBV pgRNA与肝硬化有相关性,但在这个群体中缺乏FIB-4或PAGE-B得分的独立预测能力.
目前的研究结果表明,pgRNA作为肝纤维化和HCC易感性的预测器的实用性需要进一步调查.
建议进行长度研究,以充分阐明HBVpgRNA在CHB管理中的临床意义.

关键词:

这就是CCCDNADNA.慢性乙型肝炎慢性乙型肝炎在FIB-4中,FIB-4是第一个被指控的.HBeAg 是负的我们的 NAS NAS NAS NAS 页面-B 页面-B 页面在基因前RNARNA.替代体标志物替代体标志物

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