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一个细胞组织学相关性:多发性乳腺疾病与异型性

Ismail Guzelis¹, Mehmet Ali Uyaroğlu², Irem Onur³

¹Department of Pathology, Izmir Democracy University Buca Seyfi Demirsoy Training and Research Hospital, Buca, Izmir, Turkey.

|November 28, 2025

概括

这项研究评估了通过精细针吸收细胞学 (FNAC) 诊断的异型增殖性乳腺疾病 (PBDA). 发现有44%的恶性瘤风险,在PBDA病例中,年龄较大与恶性结果显著相关.

科学领域:

在瘤学瘤学.
细胞病理学细胞病理学
乳房成像乳房成像

背景情况:

乳腺细针吸收细胞学 (FNAC) 是一个关键的诊断工具.
具有异型性扩散性乳腺疾病 (PBDA) 需要仔细的细胞病理评估.
了解PBDA的细胞组织学相关性对于患者管理至关重要.

研究的目的:

调查乳腺增殖性乳腺疾病与乳腺细针吸收细胞学 (FNAC) 诊断的缺血性乳腺疾病 (PBDA) 的细胞组织学相关性.
为了确定与PBDA诊断相关的恶性瘤的风险,在FNAC.
为了确定与PBDA病例恶性结局相关的因素.

主要方法:

在2011年1月至2020年9月期间被诊断为PBDA的乳腺FNAC病例的回顾性审查.
68个选定的PBDA病例的细胞组织学评估.
对恶性瘤风险的分析以及与患者年龄和瘤等级的相关性.

主要成果:

在3125个乳腺FNAC中,107个 (3.4%) 被诊断为PBDA.
细胞组织学评估包括68例PBDA病例,显示有44%的恶性瘤风险.
在老年患者年龄和恶性结局之间观察到统计学意义上的相关性 (P < 0.001).
根据诺丁汉分级系统,大多数恶性病例都是低等级的 (1或2).

结论:

这项研究提供了通过FNAC诊断的PBDA最大的数据集之一.
细胞病理学诊断PBDA,特别是在具有相关临床信息的老年患者中,需要进一步调查和采取行动.
细胞组织学相关性对于准确评估PBDA病例恶性瘤风险至关重要.

关键词:

亚型性亚型性亚型性亚型性乳房乳房乳房相对应关系相对应关系细胞学细胞学恶性瘤是一种恶性瘤.

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