治疗骨肉瘤的儿童和青少年的营养支持干预措施:一个范围的审查
Laura Sealy1,2, Maddie Smith2, Sarah Barrett3
1Department of Paediatric Nutrition and Dietetics, Bristol Royal Hospital for Children, Bristol, UK.
概括
对于患有骨髓瘤的儿童和年轻人来说,营养干预措施的了解很少. 需要更强大的研究来建立有效的营养支持策略,为这个群体.
科学领域:
- 儿科瘤学 儿科瘤学
- 营养科学 营养科学
- 证据综合 证据综合
背景情况:
- 骨髓瘤 (OS) 治疗显著影响儿童和青少年 (CYP) 的营养状况.
- 对于接受OS治疗的CYP患者,关于最佳营养干预措施的证据有限.
- 青少年代表了这个人口中占主导地位的年龄组,需要量身定制的研究.
研究的目的:
- 系统地绘制有关OS的CYP营养干预措施的现有证据.
- 确定对这一人口群体的营养支持方面的研究缺口.
- 为未来儿童骨髓瘤营养方面的研究方向提供信息.
主要方法:
- 根据乔安娜·布里格斯研究所和PRISMA-ScR指南进行了全面的范围审查.
- 从开始到2025年7月,在多个数据库 (MEDLINE,EMBASE,CINAHL,EMCARE,CENTRAL) 进行了搜索.
- 包括涉及25岁以下接受OS治疗的患者的研究,并应用了特定的排除标准.
主要成果:
- 包括15项研究 (2001-2024) 涉及964名参与者 (平均年龄13.3岁).
- 十项研究重点关注综合营养支持 (宏观/微量营养素),常见的是肠道营养和胃口养.
- 关键的局限性包括小队列,不完整的报告和未经验证的结果措施,只有两个随机对照试验被确定.
结论:
- 在OS的CYP中进行营养干预的证据很少,异质,并且在方法上很弱.
- 迫切需要进行大型,前性,多中心的研究.
- 未来的研究应该侧重于基于证据的策略,有效的结果措施,以及食干预措施的心理社会影响.
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