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Updated: May 5, 2026

Imaging Cell Viability on Non-transparent Scaffolds — Using the Example of a Novel Knitted Titanium Implant
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用纳米颗粒准MT-tsRNA IDDMT到纤维状圆环:一种针对椎间盘退化的新疗法

Jinghong Yuan1,2,3, Jing Ye1,2,3, Yanzhe Huang1

  • 1Department of Orthopedics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, P. R. China.

Advanced healthcare materials
|November 28, 2025
PubMed
概括

研究人员确定了一种与椎间盘退化 (IDD) 相关的新型线粒体衍生tsRNA (IDDMT). 一个新的纳米载体系统有效地提供了IDDMT抑制剂,显示了早期IDD治疗和诊断的前景.

关键词:
纤维化的圆环.这是一种炎症炎症炎症炎症.椎间盘退化 椎间盘退化线粒体中的线粒体.这就是 tsRNARNA.

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Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...
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Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...
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The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...
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