病毒疗法作为抗癌疗法的基因输送:一篇评论文章
Fakhren Nukha Zalfa1, Nurul Hikma Suciani1, Putu Ananda Arviana Dewi1
1Department of Applied Science, Faculty of Mathematics and Natural Science, Universitas Negeri Malang, Malang City, Indonesia.
Asian Pacific journal of cancer prevention : APJCP
|November 28, 2025
概括
腺病毒 (AdV) 在基因疗法中表现出高效率,使其成为癌症治疗的有希望的候选人. 需要进一步的研究来优化载体的安全性和特异性,以改善病毒治疗中的治疗结果.
科学领域:
- 在瘤学瘤学.
- 基因治疗 基因治疗
- 病毒学 病毒学
背景情况:
- 癌症仍然是全球主要的死亡原因,常规治疗,如化疗和放射治疗,导致显著的副作用.
- 基因疗法通过向癌细胞的基因来提供一种新的癌症治疗方法,有可能克服传统方法的局限性.
- 病毒载体,包括逆转录病毒,腺病毒 (AdV) 和腺相关病毒 (AAV),是基因疗法和病毒疗法的关键工具.
研究的目的:
- 本综述比较了不同病毒载体在癌症治疗中的病毒疗法的疗效.
- 综合当前关于病毒载体在向癌细胞中的有效性知识.
- 评估腺病毒 (AdV) 作为基因治疗应用的主要候选者.
主要方法:
- 进行了叙事文献审查和定性内容分析.
- 2016年至2024年间发表的超过85篇同行评审文章被系统地收集和分析.
- 搜索的数据库包括ScienceDirect,PubMed,Scopus和Nature,使用相关的关键字和布尔运算符.
主要成果:
- 腺病毒 (AdV) 具有很高的转导效率 (在肝细胞癌中高达98%) 和很大的基因容量 (37 kb),可以感染分裂和不分裂的细胞.
- 逆转录病毒表现出40%-60%的转导效率,并集成到宿主基因组中,只准分裂细胞.
- 腺相关病毒 (AAV) 的效率为30%-50%,基因容量较小 (4.8 kb),也显示出治疗潜力.
结论:
- 不同的病毒治疗药物具有独特的机制和对癌细胞的有效性.
- 腺病毒 (AdV) 由于其效率和容量,被确定为基因疗法的强有力的候选者.
- 优化载体安全性,特异性和长期结果对于最大限度地发挥病毒治疗的治疗潜力至关重要.
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