摩洛哥儿童急性淋巴细胞白血病的生存分析
Nada Bennani Mechita1,2,3, Laila Hessissen3,4, Siham Cherkaoui3,5
1Laboratory of Community Health, Preventive Medicine and Hygiene. Department of Public Health, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat. Morocco.
Asian Pacific journal of cancer prevention : APJCP
|November 28, 2025
概括
摩洛哥 摩洛哥 摩洛哥 摩洛哥 摩洛哥 摩洛哥
科学领域:
- 儿科瘤学 儿科瘤学
- 血液学 血液学 血液学
- 全球卫生倡议全球卫生倡议
背景情况:
- 世界卫生组织全球儿童癌症倡议的试点地点摩洛哥评估了儿童急性淋巴细胞白血病 (ALL) 的存活率.
- 该研究旨在估计ALL存活率,确定治疗失败的因素,并探索摩洛哥儿科血液学和瘤学 (PHO) 中心内的改善策略.
研究的目的:
- 估计摩洛哥儿童急性淋巴细胞白血病 (ALL) 的存活率.
- 确定导致儿科ALL治疗失败的因素.
- 探索改善治疗结果和生存率的途径.
主要方法:
- 对425名被诊断患有ALL的儿童 (0-15岁) 的回顾性分析.
- 卡普兰·梅尔方法用于估计生存率;日志等级测试用于比较;Cox模型用于预后因素.
- 积极的患者随访到2023年3月31日.
主要成果:
- 一年,三年和五年总生存率分别为78.7%,63.8%和60.8%.
- 关键的预后因素包括年龄,表型 (T细胞ALL与较高的死亡率相关),缓解状态和白细胞计数.
- 完全缓解诱导率为84%.
结论:
- 五年生存率为60.8%,远远低于摩洛哥到2030年实现80%的目标.
- 治疗失败的原因包括复发 (86),放弃 (34) 和毒性 (55).
- 减少放弃治疗和与毒性相关的死亡率是改善生存的可行初始策略.
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