多发性骨髓瘤和淋巴瘤的移植后感染:ASCT接受者的早期脆弱性和长期风险
Muchlis Achsan Udji Sofro1, Mila Astrilia2, Galih Prakasa Adhyatma3
1Infectious Diseases and Tropical Infection Division, Department of Internal Medicine, Faculty of Medicine, Diponegoro University, RSUP Dr. Kariadi Semarang, Indonesia.
Asian Pacific journal of cancer prevention : APJCP
|November 28, 2025
概括
在为多发性骨髓瘤和淋巴瘤进行自身干细胞移植 (ASCT) 后,感染很常见. 移植后的早期感染,通常是格拉姆阳性细菌,会带来很大的风险.
科学领域:
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
背景情况:
- 自主干细胞移植 (ASCT) 是多发性骨髓瘤 (MM) 和淋巴瘤的关键治疗方法.
- 接受ASCT的患者面临感染,发病率和死亡率的风险增加.
- 了解ASCT后的感染模式对于改善患者结果至关重要.
研究的目的:
- 分析MM和淋巴瘤患者在ASCT后的感染模式和结果.
- 为了识别常见的病原体和感染的时间.
主要方法:
- 追溯性描述性研究.
- 涉及28名MM和淋巴瘤患者接受ASCT (2013年1月 - 2023年5月).
- 从医疗记录和电话采访中收集的数据;分析感染模式,病原体和结果.
主要成果:
- 75%的患者经历了ASCT后感染,主要是在前10天内 (85%).
- 在血培养中,克拉姆阳性细菌 (52%) 比克拉姆阴性细菌 (29%) 更常见.
- 发生了三例非传染性死亡;有两例晚发性感染.
结论:
- 感染是MM和淋巴瘤的ASCT后的一个重要并发症.
- 早期的移植后感染是最常见的.
- 格拉姆阳性细菌,特别是葡萄球菌种,是主要的病原体.
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