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XRCC1 Arg399Gln遗传变异增加了结肠直肠癌的易感性:一个全面的元分析

Praveen Kumar Kampalli¹, Mohan Krishna Ghanta², Rishitha Chowdary Mavillapalli³

¹Department of Bioscience & Biotechnology, Banasthali University, Rajasthan, India.

Asian Pacific journal of cancer prevention : APJCP

|November 28, 2025

概括

XRCC1 Arg399Gln 多态性与患结直肠癌 (CRC) 的风险更高有关. 然而,其他XRCC1基因变异,Arg194Trp和Arg280His,与CRC风险没有显著关联.

科学领域:

遗传学和癌症流行病学
分子生物学和疾病风险

背景情况:

结肠直肠癌 (CRC) 是全球癌症死亡的主要原因.
在DNA修复酶中遗传的遗传变异,如XRCC1,与CRC风险有关.
之前对XRCC1多态性和CRC风险的研究已经在不同人群中产生了不一致的结果.

研究的目的:

进行全面的元分析,评估三种常见的XRCC1基因多态 (Arg194Trp,Arg280His和Arg399Gln) 与结直肠癌风险之间的关联.
综合多项病例控制研究的证据,以澄清XRCC1变异在CRC易感性中的作用.

主要方法:

一项元分析,结合了52项独立病例控制研究的数据.
具体分析包括Arg194Trp的23项研究,Arg280His的8项研究和Arg399Gln的42项研究.
使用统计方法来评估整体风险,并探索潜在的种族差异.

主要成果:

在XRCC1 Arg399Gln多态性和结直肠癌风险增加之间发现了统计学上显著的相关性 (OR = 1.10,95% CI = 1.01-1.20).
根据种族 (亚洲和高加索人种) 的子组分析没有显示任何研究的XRCC1多态和CRC风险之间存在显著的关联.
在元分析中没有发现出版偏差的证据.

结论:

XRCC1 Arg399Gln多态可能与对结直肠癌的敏感性增加有关.
XRCC1的Arg194Trp和Arg280H的多态性与结直肠癌风险没有显著关联.
可能需要进一步的研究来阐明XRCC1变异在结直肠癌发展中的确切作用.

关键词:

基因基因基因基因基因进行元分析分析.在SNP中,SNP是SNP.在XRCC1中,它是XRCC1.结肠直肠癌是什么意思

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