乳腺癌的生存结果和死亡率预测因素:来自中越南的双向队列研究
Tuyen Dinh Hoang1,2, Thang Van Vo2, Chi Thi Minh Nguyen3
1Faculty of Public Health, Khon Kaen Univerisity, Khon Kaen Province, Thailand.
Asian Pacific journal of cancer prevention : APJCP
|November 28, 2025
概括
这项在越南的研究发现,乳腺癌5年生存率为86.0%. 晚期,失业和肝脏疾病等因素使生存率恶化,而手术改善了生存率.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 乳腺癌 (BC) 是全球领先的癌症,但越南中部生存率和预后因素的数据有限.
- 这项研究解决了对越南BC患者全面生存结果数据和死亡预测因素的需求.
研究的目的:
- 估计越南中部乳腺癌患者的整体生存率.
- 确定影响该人口死亡率的关键预后因素.
主要方法:
- 从2019年1月到2023年12月,对1213名新诊断乳腺癌患者进行了一项双向队列研究.
- 卡普兰 - 梅尔方法用于OS估计;用于亚型/阶段比较的日志级别测试;用于预后因素评估的多变量考克斯模型.
主要成果:
- 一,三,五年总生存率分别为97.4%,91.0%和86.0%.
- 光线A亚型显示最好的5年生存率 (91.5%),三负最差 (76.9%). 第四阶段的疾病有29.5%的5年生存率.
- 较高的死亡风险与失业,肝病,孕激素受体阴性状态,高Ki-67指数和晚期TNM阶段 (III-IV) 有关. 手术干预与降低死亡风险相关.
结论:
- 该队列显示乳腺癌的整体生存率相对较高.
- 晚期,侵袭性瘤生物学,并发症和社会经济因素显著影响患者的结果.
- 多中心,标准化研究对于验证研究结果和改善越南和类似环境中的乳腺癌护理策略至关重要.
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