临床方法对延迟青春期的男性进行治疗
Rodolfo A Rey1, Romina P Grinspon1, Sebastián Castro1
1Centro de Investigaciones Endocrinológicas "Dr. César Bergadá" (CEDIE), CONICET - FEI - División de Endocrinología, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina.
Archives of endocrinology and metabolism
|November 28, 2025
概括
延迟的青春期在男性中很常见,涉及下丘脑-垂体-丸 (HPT) 轴. 评估包括家族病史和生物标志物,以区分原因,如自限性延迟青春期与性性性性.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 生殖内分泌学 生殖内分泌学
- 遗传学 是一个遗传学.
背景情况:
- 青春期开始和进展的障碍是儿童内分泌学家的频繁转诊.
- 延迟的青春期在男性中特别常见,影响着下丘脑-垂体-丸 (HPT) 轴.
研究的目的:
- 审查男性延迟青春期的病理生理学和临床评估.
- 为了区分自我限制的延迟青春期和低激素性低激素症.
主要方法:
- 临床评估包括家族病史,生长模式和体检.
- 对青春期发育的关键调节剂和相关生物标志物 (AMH,抑制素B,,INSL3) 的审查.
- 讨论先天性低阴腺特异性低阴腺症 (CHH) 的遗传原因.
主要成果:
- 迟到的青春期被定义为14岁时没有丸扩大.
- 自限性延迟青春期 (SLDP) 是最常见的原因,通常是家族性的.
- 功能性和永久性中央性海马体缺陷症,包括遗传性CHH,占其他病例.
结论:
- 准确诊断延迟青春期需要了解HPT轴及其调节器.
- 临床评估和生物标志物分析对于区分良性病因和病理病因至关重要.
- 遗传因素在先天性低阴腺特异性低阴腺症中起着重要作用.
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