高强度运动对风湿性关节炎患者的身体功能和疾病活动的有效性. 一个系统的审查与元分析
Iván Cuyul-Vásquez1, Oscar Catalán-Medalla2, Felipe Ponce-Fuentes3
1Departamento de Procesos Terapéuticos, Facultad de Ciencias de la Salud, Universidad Católica de Temuco, Temuco, Chile.
Journal of back and musculoskeletal rehabilitation
|November 28, 2025
概括
高强度运动与低强度运动相比,在类风湿性关节炎 (RA) 患者中没有改善身体功能或疾病活性. 然而,它在 RA 患者中安全地增强了肌肉力量和有氧能力.
科学领域:
- 类风湿病学 类风湿病学
- 运动生理学 运动生理学
- 临床试验 临床试验
背景情况:
- 关于在类风湿性关节炎 (RA) 中运动有效性的证据正在讨论中.
- 高强度运动 (HIE) 的潜在好处需要澄清.
研究的目的:
- 系统地审查HIE对RA患者身体功能和疾病活动的有效性.
- 评估HIE对肌肉力量和有氧能力的影响.
主要方法:
- 使用PROSPERO注册的随机临床试验 (RCT) 的系统审查.
- 在多个数据库 (MEDLINE,科学网,EMBASE,SCOPUS等) 进行的搜索. 在2025年9月之前.
- 两个独立的审稿人进行了研究选择,数据提取和偏差风险评估.
主要成果:
- 十一个RCT符合资格标准.
- 在20-24周,HIE与低强度运动对身体功能 (SMD=0.03) 和疾病活性 (SMD=0.06) 没有显著差异.
- 与低强度运动相比,HIE显著改善了膝盖伸展肌肉力量 (SMD=0.30) 和有氧能力 (SMD=0.35),没有报告的不良事件.
结论:
- 与低强度运动相比,HIE在RA患者中没有显著改善自我报告的身体功能或疾病活动.
- HIE是一种安全有效的干预措施,用于增强RA的肌肉力量和有氧能力.
- 需要进一步的临床试验来证实这些发现,证据质量从非常低到很高 (GRADE).
相关概念视频
01:21Rheumatic Heart Disease III: Medical Management
267
Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
267
01:20Exercise and Cardiovascular Response
3.8K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
3.8K
01:23Rheumatic Heart Disease I: Introduction
408
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
408
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
448
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
448
01:20Rheumatic Heart Disease IV: Nursing Management
251
AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
251
01:11Genome-wide Association Studies-GWAS
15.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
15.2K