基于MR神经学的客观定量参数之间的关联在下膜神经和语言神经损伤中
Mengjie Zhang1,2, Ce Zhu2,3, Hongrong Sun4,5
1Department of Oral Surgery, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
European radiology
|November 28, 2025
概括
新的定量MRI参数现在可以评估下膜神经 (IAN) 和语言神经 (LN) 的损伤. 这些发现改善了轻度至中度神经损伤患者的诊断和预后.
科学领域:
- 神经辐射学神经辐射学
- 定量成像技术 定量成像技术
- 神经损伤评估 神经损伤评估
背景情况:
- 下膜神经 (IAN) 和语言神经 (LN) 损伤的诊断通常依赖于主观的临床评估和成像,对轻度至中度病例的敏感性有限.
- 与这些神经损伤的症状严重程度和预后相关的可量化的参数目前尚未定义.
研究的目的:
- 建立定量磁共振神经图 (MRN) 参数,用于评估轻度至中度IAN和LN损伤.
- 将这些参数与临床症状学和预后结果相关联.
主要方法:
- 24名患有IAN或LN损伤的患者的回顾性审查.
- 基于MRN的参数的计算:明显信号与噪声比率 (aSNR) 和明显神经肌肉对比与噪声比率 (aNMCNR).
- 对伤害与健康比率 (aSNRi/h,aNMCNRi/h) 的分析及其与临床数据 (VAS,CPT) 和纵向结果的相关性.
主要成果:
- 与健康神经相比,在受伤的神经中观察到明显升高的aSNR和aNMCNR (p <0.05).
- aNMCNRi/h与视觉模拟尺度 (VAS) 评分和5 Hz电流感知值 (CPT) 测量结果 (p = 0.041和p = 0.048) 显示了反向相关性.
- 纵向分析显示,aNMCNRi/h与预后改善之间存在强烈的正线性关系 (p < 0.001).
结论:
- 看似的神经肌肉对比与噪声比受伤与健康比 (aNMCNRi/h) 是轻度至中度IAN/LN损伤的临床有效量化参数.
- 这个参数与症状严重程度和预后轨迹相关,为改善患者特异性管理提供了潜力.
- 这些发现支持在标准化诊断方案和优化神经损伤康复策略方面使用定量MRN.
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