甲状腺疾病对流媒体扩张的影响:系统性审查和元分析
Andrea Zaffaroni1, Daniela Gallo2,3, Sotiris Louka1
1Department of Medicine and Surgery, University of Insubria, Varese, Italy.
Journal of endocrinological investigation
|November 28, 2025
概括
甲状腺疾病影响内皮功能,通过流介导扩张 (FMD) 测量. 甲状腺功能低下会损害口炎,口炎随着治疗而改善,而甲状腺功能过高也会减少口炎,特别是在亚临床病例中.
科学领域:
- 心血管健康 心血管健康
- 内分泌学 在内分泌学.
- 血管生物学 血管生物学
背景情况:
- 甲状腺疾病与心血管风险增加有关.
- 内皮功能障碍是这种风险的潜在机制.
- 流媒扩张 (FMD) 是内皮功能的一个关键指标.
研究的目的:
- 系统地审查和对甲状腺功能 (FMD) 在甲状腺功能低下症和甲状腺功能过高症进行元分析.
- 评估甲状腺疾病治疗对口炎的影响.
- 评估甲状腺状况与心血管风险标志物之间的关联.
主要方法:
- 对Embase和PubMed数据库进行系统的文献搜索.
- 包括在低甲状腺和高甲状腺患者中评估口病的研究.
- 使用随机效应模型来计算平均差异 (MD) 和95%置信区间 (CI) 的元分析.
主要成果:
- 与对照组相比,未经治疗的甲状腺功能低下症中观察到明显减少的口病.
- 在甲状腺功能低下症患者中,Levothyroxine治疗改善了口炎,在达到安甲状腺症后使其正常化.
- 甲状腺功能障碍症,特别是亚临床的甲状腺功能障碍症,与口炎的减少有关,尽管没有偏差调整,明显甲状腺功能障碍症的结果不那么确.
结论:
- 甲状腺功能低下症与可逆性内皮功能障碍有关,这强调了甲状腺激素管理的重要性.
- 高甲状腺症,特别是亚临床形式,也可能损害内皮功能.
- 建议进一步进行高质量的研究,以证实甲状腺功能障碍的发现.
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