初始治疗失败作为新诊断的有限性性结肠炎患者近端扩张的预测因素:回顾性队列研究与倾向性得分匹配分析
Toshiyuki Sato1, Jiro Takeuchi2,3, Kazuko Nagase1
1Department of Gastroenterology, School of Medicine, Hyogo Medical University, 1-1 Mukogawa, Nishinomiya, Hyogo, 663-8501, Japan.
Digestive diseases and sciences
|November 28, 2025
概括
性结肠炎 (UC) 的初始治疗失败预示着疾病的延长和更糟糕的结果. 早期监测和治疗策略对于治疗失败的有限UC患者至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 炎症性肠道疾病研究研究
- 临床流行病学临床流行病学
背景情况:
- 性结肠炎 (UC) 通常涉及疾病的近端延伸.
- 了解影响UC进展的因素对于患者管理至关重要.
研究的目的:
- 调查初始治疗失败是否会影响有限UC患者的近端延伸.
- 确定UC疾病进展的预后因素.
主要方法:
- 对新诊断的有限UC患者 (2006-2015) 的回顾性队列研究.
- 定义初始治疗失败为3个月内没有缓解或早期复发.
- 使用倾向分数匹配 (PSM) 来控制基线差异.
- 评估近端延伸,切除术,住院和药物耐药性.
主要成果:
- 在229名患者中,68名患者 (29.7%) 在中位数9.6年的随访期内发展出近端延伸.
- 最初的治疗失败是近端延伸的一个独立风险因素 (aHR 3.2).
- 初始治疗失败组在PSM后的住院率较高.
结论:
- 最初的治疗失败是有限的UC中近端延伸的显著独立预后因素.
- 最初治疗失败的患者面临较差的长期结果.
- 建议对这些患者进行警监测和积极主动的治疗干预.
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