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肥胖中的肠道微生物组:对机制,干预措施和未来方向的叙述性审查
Ranjeet Kumar Vishwakarma1, Priyanka Gautam2, Minakshi Sahu3
1Department of Physiology, Faculty of Modern Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India.
Probiotics and antimicrobial proteins
|November 28, 2025
概括
肠道微生物群通过影响能量平衡和新陈代谢,显著影响肥胖. 针对肠道微生物群的新兴疗法对体重控制和代谢健康有很大的希望.
科学领域:
- 微生物组研究的研究.
- 代谢性疾病是一种代谢性疾病.
- 肠-大脑轴 肠-大脑轴
背景情况:
- 肥胖是一种全球性流行病,除了饮食和运动之外,其原因复杂.
- 肠道微生物群 (GM),由Firmicutes和Bacteroidetes主导,越来越多地与宿主新陈代谢和能量平衡有关.
- 由减少多样性和改变微生物组成的肠道失调症,有助于炎症和代谢功能障碍.
研究的目的:
- 审查肠道微生物群在肥胖病原发生中的作用.
- 探索转基因生物影响荷尔蒙调节和能量平衡的机制.
- 以突出新兴的微生物向治疗肥胖的治疗方法.
主要方法:
- 文献综述综合了关于肠道微生物群和肥胖的当前研究.
- 分析机制,包括SCFA生产和荷尔蒙调节 (叶丁, ghrelin 等) 的分析. ) 的情况.
- 检查肠-大脑轴与食欲和能量平衡的关系.
主要成果:
- 转基因成分和功能对于调节宿主能量收获,炎症和代谢健康至关重要.
- 微生物代谢物和激素信号通路是转基因生物和宿主生理学之间的关键调解者.
- 针对微生物组的干预措施,如益生菌,益生菌和FMT显示出潜力,但需要进一步验证.
结论:
- 肠道微生物群在肥胖的发展和荷尔蒙调节中起着重要作用.
- 基于微生物组的疗法为预防和治疗肥胖提供了有希望的途径.
- 通过将转基因数据与宿主遗传学和环境因素相结合,可以实现个性化肥胖管理.
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