母乳乳杆菌 Lactobacillus Gasseri FN136 通过微生物群独立的代谢物与宿主相互作用缓解DSS诱导的性结肠炎
Qingcui Li1, Wenhao Wang1, Fan Zhou1
1Institute of Nutrition and Health, Qingdao University, Qingdao, 266071, China.
Probiotics and antimicrobial proteins
|November 28, 2025
概括
乳酸菌 (Lactobacillus gasseri) FN136是一种益生菌,在DSS诱导的模型中有效降低了性结肠炎 (UC) 症状. 它通过后生物宿主途径起作用,而不是通过改变肠道微生物群组成.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 性结肠炎 (UC) 是结肠的慢性炎症状况,增加了结肠直肠癌的风险.
- 益生菌被探索为UC管理的辅助疗法.
研究的目的:
- 评估乳酸菌 (Lactobacillus gasseri FN136) - - 一种母乳衍生益生菌 - - 作为治疗性结肠炎的干预措施的有效性.
- 阐明FN136在减轻大肠炎中的作用机制.
主要方法:
- 在体外评估FN136的抗炎性质,耐受性和抗菌活性.
- 在体内研究使用DSS诱导的大肠炎模型在小鼠中,每天口服FN136.
- 对血清标志物,免疫细胞种群,结肠组织学和全身炎症标志物的分析.
- 16S rRNA测序以评估肠道微生物组成的变化.
主要成果:
- FN136在体外表现出抗炎性质和耐受性.
- 在体内,FN136显著减弱了DSS诱导的UC,减少了疾病活性,体重减轻和结肠损伤.
- FN136恢复了血清L-氨酸,增加了脏调节T细胞,并增加了氧化的产生.
- 系统性炎症标志物 (IL-6,MPO,LPS,FITC-dextran) 显著降低.
- 通过16S rRNA测序,没有观察到全球微生物组成的显著变化.
结论:
- 乳杆菌毒素FN136通过微生物群独立的后生物宿主轴减轻DSS诱导的UC.
- FN136可恢复血清中阿尔金因,并增强免疫屏障恒温,为UC干预提供了一种新的方法.
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