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Updated: Jan 6, 2026

Multi-color Localization Microscopy of Single Membrane Proteins in Organelles of Live Mammalian Cells
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在拥挤的细胞冷电子断层扫描中定位宏分子,来自极其稀疏的标签.

Mostofa Rafid Uddin1, Ajmain Yasar Ahmed2, H M Shadman Tabib3

  • 1Ray and Stephanie Lane Computational Biology Department, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213, United States.

Briefings in bioinformatics
|November 28, 2025
PubMed
概括

TomoPicker 通过使用最小的注释,有效地定位了冷电子断层扫描 (cryo-ET) 图像中的宏分子. 与传统方法相比,这种新的方法显著降低了数据需求,使得现场结构性确定速度更快.

关键词:
三维分类是3D分类.细胞和结构生物学.冷电子断层扫描 (Cryo-electron tomography) 是一种电子断层扫描技术.大分子局部化定位.积极的没有标记的学习.

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