变压器和图形变异自编码器用于识别微环境:用于空间转录组学的深度学习协议
Karla Paniagua1, Yufei Huang2, Shou-Jiang Gao3
1Department of Electrical and Computer Engineering, KLESSE School of Engineering and Integrated Design, University of Texas at San Antonio, San Antonio, TX 78249, USA.
STAR protocols
|November 28, 2025
概括
我们使用变压器和图形变化自编码器开发了一个计算框架,用于识别空间微环境 (TG-ME). 这种深度学习方法可以在各种组织类型中实现强大的利基集群.
科学领域:
- 计算生物学是一种计算生物学.
- 生物信息学是一种生物信息学.
- 空间转录组学 空间转录组学
背景情况:
- 了解组织微环境对于疾病研究至关重要.
- 空间转录和形态成像为利基分析提供了补充数据.
研究的目的:
- 介绍一个计算框架,TG-ME,用于剖析空间.
- 整合空间转录学和形态数据用于微环境识别.
主要方法:
- 使用变压器和图形变量自动编码器 (TG-ME).
- 实现数据规范化和形态特征提取.
- 应用深度学习来实现强大的利基集群.
主要成果:
- TG-ME成功地整合了各种空间数据.
- 该框架使空间利基的有效聚类成为可能.
- 适用于健康,瘤和受感染的组织.
结论:
- TG-ME为空间利基分析提供了一个强大的工具.
- 计算框架增强了对组织微环境的理解.
- 深度学习的整合促进了强大的微环境识别.
相关概念视频
Transformers in Distribution System
485
Transformers in distribution systems can be broadly categorized into distribution substation transformers and other distribution transformers. They are crucial for stepping down high transmission voltages to levels suitable for distribution and end-user applications.
Distribution substation transformers come in various ratings and typically use mineral oil for insulation and cooling. To prevent moisture and air from entering the oil, some transformers use an inert gas like nitrogen to fill the...
Distribution substation transformers come in various ratings and typically use mineral oil for insulation and cooling. To prevent moisture and air from entering the oil, some transformers use an inert gas like nitrogen to fill the...
485
Types Of Transformers
1.4K
Transformers can provide desired voltages to a circuit by modifying the number of turns in the secondary windings.
If the ratio of the number of turns in the secondary winding to that of the primary winding is greater than one, then the transformer is said to be a step-up transformer. In a step-up transformer, the voltage at the secondary winding is greater than the voltage applied at the primary winding.
However, if this ratio is less than one, the transformer is said to be a step-down...
If the ratio of the number of turns in the secondary winding to that of the primary winding is greater than one, then the transformer is said to be a step-up transformer. In a step-up transformer, the voltage at the secondary winding is greater than the voltage applied at the primary winding.
However, if this ratio is less than one, the transformer is said to be a step-down...
1.4K
Neural Circuits
2.6K
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
2.6K
Extraction: Advanced Methods
1.0K
Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
1.0K


