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在心脏突然死亡中,左心室喷射分数和心肌纤维化导致心脏突然死亡

Harri Silvola¹, Lauri Holmström¹, Lasse Pakanen^2,3

¹Research Unit of Biomedicine and Internal Medicine, Medical Research Center Oulu, University of Oulu, Oulu University Hospital, OYS Sydän, Kajaanintie 50, Oulu 90220, Finland.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

|November 28, 2025

概括

突然心脏死亡 (SCD) 风险通常通过左心室喷射率 (LVEF) 来评估. 然而,LVEF与心肌纤维化的相关性很差,这是SCD患者的常见发现,这表明LVEF是纤维化的不可靠指标.

科学领域:

心脏病学心脏病学
病理学病理学病理学
法医医学法医医学

背景情况:

左心室喷射率 (LVEF) 是评估突然心脏死亡 (SCD) 风险的主要指标.
心肌纤维化越来越被认为是各种心脏病的重要因素.

研究的目的:

在基于人口的SCD受害者队列中确定LVEF的频谱.
评估心肌纤维化和SCD前LVEF之间的关联.

主要方法:

从北芬兰 (1998-2017年) 的尸检验证SCD病例 (n=5869) 的分析.
对心肌纤维化程度的宏观和组织学评估.
从电子健康记录中对死前心声回声学数据 (LVEF) 的评估.

主要成果:

显著比例的SCD受害者表现出心肌纤维化 (显著:19.6%,中度:53.8%).
只有15.4%的SCD受试者严重减少了LVEF (≤35%).
在心肌纤维化程度和LVEF之间发现了微弱的相关性 (斯皮尔曼 ρ 0.21).

结论:

心肌纤维化的患病率在SCD患者中很高,而严重降低的LVEF较少见.
左心室喷射分数与心肌纤维化程度的相关性较弱.
在经历过SCD的个体中,LVEF是评估心肌纤维化的一个不可靠的替代品.

关键词:

心脏骤停是因为心脏停止了.心声回声扫描 (Echocardiography) 是一种心声回声扫描.喷射分数的喷射分数是什么心肌纤维化是心肌纤维化的一种.突然死亡是突然死亡.

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