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Microfluidic Assay for the Assessment of Leukocyte Adhesion to Human Induced Pluripotent Stem Cell-derived Endothelial Cells hiPSC-ECs

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使用阻抗-变形性细胞计进行无标签白细胞生物物理分析,用于快速心血管风险分层.

Linwei He¹, Hui Min Tay¹, Feng Chen²

¹School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, Singapore.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|November 28, 2025

概括

此摘要是机器生成的。

一种新的微流体方法分析中性粒细胞特性,以预测2型糖尿病 (T2DM) 中心血管疾病 (CVD) 风险. 这种技术为糖尿病患者早期心血管疾病风险分层提供了一种具有成本效益的方法.

关键词:

生物物理概况分析 (biophysical profiling) 是一种生物物理概况分析.糖尿病糖尿病患者糖尿病患者阻抗细胞计阻抗细胞计微流体学在微流体学方面翻译诊断是一种翻译诊断.

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科学领域:

生物医学工程生物医学工程
心血管研究研究心血管研究
糖尿病学糖尿病学

背景情况:

2型糖尿病 (T2DM) 是一个主要的全球健康问题,心血管疾病 (CVD) 是死亡的主要原因.
在T2DM患者中有效的心血管疾病风险分层对于及时干预和改善患者结果至关重要.

研究的目的:

开发一种快速,无标签的微流体工作流程,用于评估T2DM患者的心血管风险.
调查中性粒细胞生物物理异常作为T2DM中心血管疾病风险的潜在生物标志物.

主要方法:

采用了一种高通量单细胞微流体技术,称为"电力机械表型".
白细胞的生物物理特性 (大小,可变形性,阻抗) 使用统一多重近似和投影 (UMAP) 进行了分析.
该方法在体外和糖尿病和动脉样硬化倾向的小鼠模型中得到了验证,随后进行了一项临床研究.

主要成果:

患有心血管疾病 (DM-CVD) 的糖尿病患者表现出明显的中性粒细胞阻抗特征和亲炎性转录组形状.
确定的关键分子通路包括细胞骨失调和DM-CVD中性粒细胞中改变的RhoA信号传递.
主要组件分析在识别血管功能障碍的个体中显示出高准确度 (AUC = 0.971).

结论:

中性粒细胞阻抗分析是T2DM中心血管风险分层的一个有希望的,具有成本效益的策略.
开发的微流体工作流程可以快速,无标签地评估心脏病风险.
生物物理中性粒细胞分析提供了有关T2DM,炎症和心血管疾病联系的机制的见解.