父母暴露于六烯氧化物三酸诱导斑马鱼的跨代发育毒性和甲状腺内分泌干扰效应
Xiaohui Zhao1, Dan Yang1, Jorke H Kamstra2
1College of Environmental Science and Engineering, Dalian Maritime University, Dalian 116026, China.
Ecotoxicology and environmental safety
|November 28, 2025
概括
父母暴露于氧化氧化三分酸 (HFPO-TA) 导致斑马鱼后代的发育和甲状腺问题. 这些影响与通过DNA甲基化对基因失调有关,影响中枢神经系统和甲状腺激素通路.
科学领域:
- 环境毒理学环境毒理学
- 发展生物学 发展生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 六烯氧化物三酸 (HFPO-TA) 是一种在水生环境中发现的PFOA替代品.
- 关于HFPO-TA在鱼类中的跨代毒性和机制的数据有限.
研究的目的:
- 研究斑马鱼中HFPO-TA的跨代发育毒性.
- 阐明潜在的机制,包括甲状腺干扰和表观遗传修饰.
主要方法:
- 成年斑马鱼 (F0) 在90天内暴露在不同度的HFPO-TA (0-50μg/L) 中.
- 对后代 (F1,F2) 的跨代影响被评估为发育和甲状腺终点.
- 对基因表达,甲状腺激素水平和DNA甲基化进行了跨代分析.
主要成果:
- 在F0鱼类中,HFPO-TA暴露导致F1和F2后代的心率降低和旋转逃逸.
- 甲状腺干扰,甲状腺激素稳定性改变和基因表达变化在三代人中被观察到.
- 关键基因促进体中的DNA甲基化修饰被确定为HFPO-TA诱导毒性的机制.
结论:
- 父母暴露于HFPO-TA会诱导斑马鱼的跨代毒性,这种毒性是由表观遗传失调所介导的.
- 甲状腺干扰和发育影响与改变的基因表达和DNA甲基化模式有关.
- 研究结果强调需要进一步关注HFPO-TA在水生生态系统的长期和跨代影响.
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