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在Crassostrea gigas中,DBDPE比BDE-209诱导了更持久的干扰:肠道微生物组调节的生理反应

Lei Liu¹, Tao Sun¹, Chenglong Ji²

¹Shandong Key Laboratory of Coastal Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China; University of Chinese Academy of Sciences, Beijing 100049, China.

Aquatic toxicology (Amsterdam, Netherlands)

|November 28, 2025

概括

甲二乙烯 (BDE-209) 和其替代品,甲二乙烯 (DBDPE),对海构成风险. DBDPE导致了更严重的肠道微生物组和代谢组变化,挑战了其更安全的地位.

科学领域:

环境毒理学环境毒理学
海洋生物学海洋生物学
微生物组研究微生物组研究

背景情况:

像BDE-209和DBDPE这样的制阻燃剂 (BFR) 是全球海洋污染物.
BFRs通过肠道微生物组和代谢组的改变影响海洋生物的健康.
了解BFR的影响和恢复对于海洋生态系统健康至关重要.

研究的目的:

研究BDE-209和DBDPE对太平洋肠道微生物组和代谢组的影响.
评估BFR暴露后的生物积累,净化和回收机制.
阐明肠道微生物组在介导BFR诱导的不良影响中的作用.

主要方法:

太平洋暴露在BDE-209/DBDPE (1和100μg l−1) 中28天,然后进行14天的净化.
对肠道微生物组合,代谢和宿主生理反应 (氧化应激,细胞损伤) 的分析.
相关性网络分析,以将微生物和宿主对BFR暴露的反应联系起来.

主要成果:

与BDE-209相比,DBDPE显示出更高的生物积累,并诱导了比BDE-209更严重的肠损伤,氧化应激和细胞膜损伤.
不良影响,包括病原体的扩散,在净化过程中在DBDPE暴露的中持续存在.
在净化过程中,肠道微生物组和宿主新陈代谢 (纯素,甘油脂) 进行了重塑,Verrucomicrobiota在肠道屏障恢复中发挥了作用.

结论:

由于DBDPE的持续不良影响,其作为BDE-209.9更安全的替代品的地位受到挑战.
肠道微生物组在调解中的BFR毒性和恢复过程中发挥着关键作用.
涉及微生物和代谢途径的宿主修复机制有助于消除,但不能完全逆转DBDPE的损害.

关键词:

生物积累生物积累生物积累甲基甲基乙烯 (Decabromodiphenyl ethane) 是一种甲基甲基乙烯 (Decabromodiphenyl ethane) 的一种化合物.甲基二乙烯乙醇是什么?肠道代谢组是肠道的代谢组.我们的肠道微生物组.

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