夜间尿尿失禁的多睡眠学和自主功能特征:一项观察性研究
Parag Thosare1, Biswaroop Chakrabarty2, Sheffali Gulati3
1Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
Pediatric neurology
|November 28, 2025
概括
主要单症状夜间尿泡症 (PMNE) 通常涉及睡眠障碍和行为问题. 同时出现的睡眠障碍,特别是与睡眠相关的运动障碍 (SRMD),预测PMNE对标准行为疗法的反应不佳.
科学领域:
- 儿科睡眠医学 儿科睡眠医学
- 自主神经病学 自主神经病学
- 行为儿科 行为儿科
背景情况:
- 主要单症状夜间尿尿 (PMNE) 的评估已经产生了不一致的结果.
- 为了更好地理解和治疗PMNE,需要同时评估多睡眠学和自主功能.
研究的目的:
- 为了同时评估PMNE儿童的夜间多睡眠学和自主功能.
- 阐明PMNE的病理生理学,并确定影响治疗反应的因素.
主要方法:
- 患有PMNE的5至18岁儿童接受了夜间的多睡眠学和自主功能测试.
- 心理评估包括睡眠评估,行为检查清单和人格测试.
- 参与者接受了为期12周的标准行为治疗.
主要成果:
- 71.4%的PMNE病例患有与睡眠有关的呼吸障碍,61.9%患有与睡眠有关的运动障碍 (SRMD).
- 与对照组相比,PMNE患者的睡眠效率较低,睡眠阶段分布发生变化.
- 自主功能显示了最小的日间交感变异;SRMD与治疗反应不佳有关.
结论:
- PMNE可能涉及多巴胺耗尽,特别是在睡眠障碍和SRMD患者中.
- 睡眠障碍和SRMD是影响PMNE治疗结果的重要因素.
- 研究结果表明,在特定的PMNE病例中,多巴胺调节可能具有治疗意义.
相关概念视频
Narcolepsy
466
Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
466
REM Sleep Behavior Disorder
1.3K
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
RBD is significantly associated with...
1.3K
Sleep-Wake Cycles
2.7K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
2.7K
Urodynamic Studies: Uroflowmetry
3.1K
Uroflowmetry is a non-invasive urodynamic test designed to measure various aspects of urination, including volume, flow rate, and the time to void. This test is crucial for diagnosing and assessing conditions such as bladder outlet obstruction, bladder dysfunction, incomplete bladder emptying, incontinence, and urinary tract blockages caused by benign prostatic hyperplasia (BPH) and urethral strictures.Pre-Test Instructions:Before a uroflowmetry test, patients are typically advised to drink...
3.1K
Restless Leg Syndrome and Night Terrors
462
Restless Leg Syndrome (RLS), also known as Willis-Ekbom disease, is a neurological disorder characterized by an uncontrollable urge to move the legs due to uncomfortable sensations. These sensations typically occur during periods of rest or inactivity, particularly when lying down or sitting, and can severely disrupt sleep.
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...
462
Substance Use Disorders Affecting Sleep
369
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
369


