失调的中性粒细胞通过增强骨质细胞形成促进性骨质疏松症的骨损失:综合生物信息学和实验验证的见解

失调的中性粒细胞通过增强骨质细胞形成促进性骨质疏松症的骨损失:综合生物信息学和实验验证的见解

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Tingwei Lu¹, Zhirui Dong², Lingyong Jiang¹

¹Center of Craniofacial Orthodontics, Department of Oral and Cranio-maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Shanghai Research Institute of Stomatology, Shanghai 210000, China.

International immunopharmacology

|November 28, 2025

概括

中性粒细胞功能障碍有助于性骨质疏松症 (ROD) 的骨损失. 损伤的中性粒细胞恶化骨质细胞活性,突出显示了这种慢性病并发症的新治疗标.

科学领域:

免疫学免疫学免疫学
骨生物学骨生物学骨生物学
腎臟病學 (nephrology) 是一種醫學專業.

背景情况:

脏骨质疏松症 (ROD) 是慢性脏病 (CKD) 的严重骨并发症.
中性粒细胞在骨质平衡中起着关键作用,但它们在ROD中的功能尚不清楚.
ROD中的骨免疫微环境涉及影响骨重塑的复杂相互作用.

研究的目的:

研究中性粒细胞在ROD骨微环境中的作用和功能状态.
阐明中性粒细胞在ROD中导致骨代谢失衡的机制.
确定潜在的生物标志物和治疗策略来管理ROD.

主要方法:

在ROD患者和小鼠ROD模型中进行转录基因分析.
生物信息分析和对中性粒细胞功能的实验验证.
共同培养系统以评估中性粒细胞-巨细胞相互作用和骨质细胞生成.
潜在的治疗点的in silico和in vitro验证.

主要成果:

ROD表现出骨质稳定性受损和骨质疏松性表型,骨质细胞活性增加.
在ROD微环境中的中性粒细胞表现出功能障碍:降低脱粒化,NET形成和丰度.
ROD中性粒细胞通过PI3K-Akt通路的介导,通过细胞因子释放促进骨质结晶形成.
确定了潜在的生物标志物和ROD的治疗化合物.

结论:

中性粒细胞功能障碍是导致ROD病理性骨损失的关键因素.
损伤的中性粒细胞会破坏骨质细胞生成和骨质生成之间的平衡.
向中性粒细胞功能为ROD管理提供了一个有希望的治疗途径.

关键词:

慢性脏疾病慢性脏疾病中性粒细胞中的中性粒细胞.骨质细胞生成 (Osteoclastogenesis) 是一个过程.骨质免疫微环境是一个微环境.脏骨质疏松症脏骨质疏松症

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