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细胞代谢生物传感:从细胞外微环境到细胞内生理监测

Tao Liang¹, Chenlei Gu², Jiaru Fang³

¹Department of Chemistry, Zhejiang-Israel Joint Laboratory of Self-Assembling Functional Materials, ZJU-Hangzhou Global Scientific and Technological Innovation Center, School of Medicine, Zhejiang University, Hangzhou, 310058, China; Laboratory Medicine Center, Department of Transfusion Medicine, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China.

Biosensors & bioelectronics

|November 28, 2025

概括

本综述涵盖了使用微生理系统中集成的生物传感器进行细胞代谢监测的进展. 它强调了对关键代谢物的无标签,连续跟踪方法,以了解细胞功能.

科学领域:

生物技术是生物技术.
细胞生物学细胞生物学
生物化学生物化学

背景情况:

细胞代谢对于生物体的生长和功能至关重要.
在细胞培养中监测细胞代谢对于生物研究至关重要.
现有的电化学和光学传感器分析细胞外代谢物,如葡萄糖和氧气.

研究的目的:

通过使用集成生物传感器,批判性地评估细胞代谢监测的进展.
专注于微生理系统 (细胞培养检测系统) 内的生物传感器利用.
分析影响细胞过程的代谢途径和关键代谢物.

主要方法:

关于细胞代谢监测的科学文献的全面审查.
代谢途径和关键代谢物 (例如质子,氧,葡萄糖,乳酸) 的分析.
探测分析剂,机制,系统,培养和应用在多式联络生物传感中的讨论.

主要成果:

电化学和光学传感器使得无标签,非侵入性和不断监测代谢物.
微生理系统中集成的生物传感器提供了超越静态测试的洞察力.
该审查讨论了各种传感技术及其应用,包括商业产品.

结论:

生物传感技术在监测细胞代谢方面取得了重大进展.
需要进一步开发以提高临床和科学需求的传感能力.
未来的方向包括改善生物传感器系统,以便进行更先进的代谢分析.

关键词:

细胞代谢物的细胞代谢物.细胞外微环境监测监测代谢途径代谢途径微生理系统是微生理系统.多模式生物传感器

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