高强度间歇训练优于适度运动,以改善近期出现异常性炎症肌肉病的患者的有氧能力:一个多中心随机对照试验
Kristofer M Andreasson1, Cecilia Leijding2, Maryam Dastmalchi3
1Karolinska University Hospital, Theme Women's Health and Allied Health Professionals, Medical Unit Allied Health Professionals, Stockholm, Sweden; Division of Rheumatology, Department of Medicine, Karolinska Institutet, Solna, Stockholm, Sweden.
高强度间歇训练 (HIIT) 在患有异常性炎症性肌肉病 (IIM) 的患者中显著改善了有氧能力,肌肉耐力和线粒体功能. 这种安全的运动干预措施显示出作为IIM管理的辅助治疗的前景.
科学领域:
- 运动生理学 运动生理学
- 类风湿病学 类风湿病学
- 线粒体生物学 线粒体生物学
背景情况:
- 异形性炎症性肌肉病变 (IIM) 是一种影响肌肉的慢性自身免疫性疾病.
- 目前的管理通常涉及标准的炼方案,对关键的生理标志物的影响有限.
- 研究新的运动干预措施,如高强度间歇训练 (HIIT),对于改善患者的治疗结果至关重要.
研究的目的:
- 为了比较HIIT与常规 (CON) 低至中等强度运动的疗效和安全性,在近期IIM患者中进行.
- 评估HIIT对有氧能力,肌肉耐力和线粒体功能的影响.
- 在这个患者群体中评估HIIT的耐受性和安全性.
主要方法:
- 23名IIM患者被随机分配到HIIT或CON组12周.
- HIIT涉及监督的会话,其频率根据个人耐受性进行调整.
- CON组遵循了标准的家庭练习,进行了一次监督会议.
- 结果包括心肺健康 (VO2峰值,峰值功率,耗尽时间),肌肉线粒体蛋白质表达和疾病活动标志物.
主要成果:
- 与CON (1.8%) 相比,HIIT显著增加了VO2峰值 (16%).
- 峰值功率和耗尽时间显示,HIIT (18%,23%) 与CON (8%,12%) 相比,HIIT有更大的改善.
- 肌肉活检表明HIIT组中线粒体蛋白质表达增加,这表明线粒体功能增强. 这两种干预都保持了稳定的疾病活动标志物.
结论:
- 高强度间歇训练 (HIIT) 是一种安全有效的运动方式,用于改善近期IIM患者的心肺健康,肌肉耐力和线粒体功能.
- HIIT显示出作为IIM标准治疗的有效辅助疗法的潜力.
- 这种运动方法可以为IIM患者提供显著的健康益处.
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