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对dsRNA污染对mRNA疫苗表达和免疫原性影响的系统性评估

Sohee Jo1, Jisun Lee2, Sang-In Park3

  • 1Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon 14662, Republic of Korea; BK21 four Department of Biotechnology, The Catholic University of Korea, Gyeonggi-do, Bucheon, Republic of Korea.

Journal of controlled release : official journal of the Controlled Release Society
|November 28, 2025
PubMed
概括

在信使RNA (mRNA) 疫苗中的双链RNA (dsRNA) 污染可能会降低有效性. 低的dsRNA水平可能会提高免疫力,但高水平会抑制抗原表达和适应性免疫反应,影响疫苗的安全性.

关键词:
这是一种双链RNA.人类乳头瘤病毒E7在体外转录 In vitro转录流感的血液凝聚素是流感的血液凝聚素这是一种N1-甲基伪尤里丁.这是mRNA疫苗.

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