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表面活性剂作为通过皮肤透的增强剂:结构,机制和应用

Zhijuan Yin¹, Xuan Chen¹, Huaming He¹

¹Beijing Technology and Business University, College of Light Industry Science and Engineering, Academy for Interdisciplinary Studies, Beijing 100048, China.

International journal of pharmaceutics

|November 28, 2025

概括

表面活性剂通过改变皮肤屏障来增强活性化合物的皮肤透性. 本综述探讨了各种表面活性剂类型和优化药物和化品通过皮肤递送的机制.

科学领域:

制药科学制药科学
材料科学材料科学材料科学
皮肤病学皮肤病学

背景情况:

表面活性剂具有独特的物理化学特性,可以改变皮肤屏障的功能.
这种修改增强了活性化合物的透皮透性.
使用各种表面活性剂类型,包括阴离子,阴离子,离子,无离子,生物表面活性剂和混合系统.

研究的目的:

审查利用不同类型的表面活性剂来促进通过皮肤透.
讨论影响表面活性剂在通过皮肤递送中的疗效的因素.
突出应用,安全问题和基于表面活性剂的透皮系统的未来方向.

主要方法:

通过皮肤传递表面活性剂应用的文献综述.
影响表面活性剂有效性的物理化学性质的分析 (例如,头组,链条长度,形状,性).
检查表面活性剂对角层作用的介导作用机制.

主要成果:

表面活性剂通过改变角层蛋白质,破坏脂质基质和改善活性物质的溶解性/扩散性等机制来增强皮肤间的透.
诸如头组,疏水链长度,分子构造和组件形成 (,囊泡,微乳液) 等因素显著影响增强.
表面活性剂在通过皮肤递送药物和化品中具有广泛的应用性.

结论:

表面活性剂是各种应用中通过皮肤透的有效增强剂.
表面活性剂的合理设计和选择对于有针对性和高效的交付至关重要.
需要进一步的研究来解决安全问题,并优化基于表面活性剂的输送系统.

关键词:

申请申请表申请表透机制透机制结构因素结构因素表面活性剂是一种表面活性剂.通过皮肤透通过皮肤透.

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