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用于神经组织电刺激的磁电核心外纳米粒子:在体外和体外有机型培养物中的性能

Maurizio Gulino¹, Donghoon Kim², Qiao Tang²

¹i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, R. Alfredo Allen 208, 4200-135 Porto, Portugal; INEB - Instituto de Engenharia Biomédica, Universidade do Porto, R. Alfredo Allen 208, 4200-135 Porto, Portugal; FEUP - Faculdade de Engenharia da Universidade do Porto, s/n, R. Dr. Roberto Frias, 4200-465 Porto, Portugal.

Acta biomaterialia

|November 28, 2025

概括

新的生物相容磁电纳米粒子 (CFO-BCZT) 显示出对非侵入性脑刺激疗法的前景. 这些功能纳米粒子提供了卓越的生物相容性和有效的神经组织透,为先进的神经调制铺平了道路.

科学领域:

纳米技术纳米技术
材料科学材料科学材料科学
神经科学是一个神经科学.

背景情况:

磁电纳米粒子 (MENPs) 正在成为非侵入性大脑刺激的工具.
开发具有有效神经应用能力的生物相容MENP至关重要.

研究的目的:

为了合成和评估基于铁素的纳米颗粒,涂上/酸酸 (CFO-BCZT),用于神经应用.
评估CFO-BCZT MENPs的磁电合,生物相容性和组织透.

主要方法:

核心外CFO-BCZT MENPs的水热和阳光凝合成.
用X射线衍射进行结构分析.
磁电合的压响应力显微镜.
在神经元和质细胞上的体外和体外细胞毒性测定.
机体类型的海马切片培养物用于长期影响和组织透研究.
对SH-SY5Y神经元细胞系的磁刺激.

主要成果:

CFO-BCZT MENPs展示了一个立方CFO核心和四角形BCZT外,没有杂质.
证明了显著的磁电合.
与CFO-BFO和未涂层CFONP相比,在体外和体外表现出更好的生物相容性.
在没有细胞损伤的情况下,在器官类型的大脑切片中实现了磁吸引引导的组织透.
在磁刺激下促进神经元细胞系中神经元细胞的生长.

结论:

CFO-BCZT MENPs具有强大的磁电合和增强的生物相容性.
这些MENP适用于非侵入性神经调制和脑刺激疗法.
该研究强调了使用多功能纳米材料的安全无线脑刺激平台的潜力.

关键词:

生物相容性生物相容性磁电纳米粒子磁电纳米粒子纳米粒子磁性导向指导神经刺激的神经刺激有机类型的大脑培养.

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