情绪性饮食和与代谢功能障碍相关的脂肪性肝病 (MASLD):在临床人群中进行了一项预先注册的研究
Marisol Vazquez1, Laura L Wilkinson2, Tom Pembroke1
1University Hospital of Wales, Cardiff and Vale University Health Board, Heath Park, Cardiff, CF 14 4XW, United Kingdom.
Physiology & behavior
|November 28, 2025
概括
情绪化的饮食和不健康的零食与代谢功能障碍相关的脂肪性肝病 (MASLD) 和肝脂肪有关,由体重指数 (BMI) 介导. 针对情绪性饮食的心理治疗可能有助于管理MASLD.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
- 行为科学 行为科学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 影响全球38%的成年人,造成严重的健康和经济负担.
- 肥胖与MASLD密切相关,而饮食行为可能是一个未被充分探索的共同风险因素.
- 了解饮食行为,肥胖和肝脏健康之间的相互作用对于开发有效干预措施至关重要.
研究的目的:
- 通过身体质量指数 (BMI) 测试一种调解模型,研究情绪和不受控制的饮食,肝纤维化 (kPa) 和脂肪酸症 (CAP) 之间的联系.
- 探索情绪性饮食和BMI对MASLD,与酒精有关的肝病 (ArLD) 和肝功能障碍的其他原因的预测价值.
主要方法:
- 一组129名接受纤维扫描的英国患者完成了关于饮食行为,零食和酒精消费的验证问卷.
- 一个调解模型被用来通过BMI分析饮食行为对肝脏参数的间接影响.
- 后勤回归检查了情绪性饮食和BMI对不同类型肝病的预测能力.
主要成果:
- 情绪性饮食间接与肥胖症相关,以BMI为媒介 (P=0.002).
- 不健康的零食消费与肥胖症有直接关联 (P=0.04).
- 情绪性饮食和BMI积极预测了MASLD状态,而较低的情绪性饮食预测了ArLD.
结论:
- 针对情绪性饮食的心理干预可能是管理MASLD的有希望的策略.
- 饮食行为,特别是情绪性饮食,在MASLD的发展和进展中起着重要作用.
- 这些发现强调了多学科方法对MASLD的重要性,整合了行为和代谢干预措施.
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