超越"理想"候选人:克罗恩氏病排除饮食在围疾病中的潜力 - 一个案例报告
Konstantina Morogianni1, Aikaterini Mountaki2, Dimitrios Karayiannis3
1Laboratory of Dietetics and Quality of Life, Department of Food Science and Human Nutrition, School of Food and Nutritional Sciences, Agricultural University of Athens, 75 Iera Odos Street, 11855 Athens, Greece.
Clinical nutrition ESPEN
|November 28, 2025
概括
部分肠道营养 (PEN) 的克罗恩氏病排除饮食 (CDED) 显示出对管理围性克罗恩氏病 (CD) 的承诺. 这种饮食方法导致患者的炎症和关闭减少,从而允许降低药物升级.
科学领域:
- 胃肠病学 胃肠病学
- 临床营养学 临床营养学
- 炎症性肠道疾病研究研究
背景情况:
- 克罗恩病 (CD) 管理正在不断发展,人们对饮食疗法的兴趣越来越大.
- 周围CD在治疗和患者结果方面存在独特的挑战.
- 克罗恩氏病排除饮食 (CDED) 与部分肠道营养 (PEN) 结合,被探索为一种治疗选择.
研究的目的:
- 为了记录患者的临床和人体测量结果,与CDED加PEN.治疗的活跃的近口CD.
- 评估这种饮食干预对生活质量 (QoL) 的影响.
- 为了评估CDED加PEN在具有挑战性的CD病例中作为辅助治疗的疗效.
主要方法:
- 一名31岁的男性患者曾经接受过手术治疗,患有大肠透性CD和复发性发作.
- 多相CDED与PEN相结合,最初是作为辅助治疗.
- 在整个治疗期间,临床,生化和内镜参数都被监测.
主要成果:
- 12周后,患者表现出三年来最低的炎症标志物,管排水显著减少.
- 内镜改善允许降低Infliximab (IFX) 的升级和清除塞顿.
- 干预后两年,患者在临床上保持稳定,没有爆发或额外的药物治疗,坚持CDED维护饮食.
结论:
- 本案例报告提供了CDED作为围CD可行的补充疗法的初步证据.
- 结合CDED和PEN可以在管理复杂的外腔CD病例时提供显著的好处.
- 需要进一步的研究,以在更大的队列中证实这些发现.
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