患有SARS-CoV-2的儿童发烧缓解后手术的时间:一个前性队列研究
Yi Lu1, Longxiang Lin1, Changyuan Liu1
1Department of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University; Key Laboratory of Pediatric Anesthesiology, Ministry of Education, Wenzhou Medical University; Key Laboratory of Anesthesiology of Zhejiang Province, Wenzhou Medical University, 109 West Xueyuan Road, Wenzhou, China.
BMJ open respiratory research
|November 28, 2025
概括
患有SARS-CoV-2 (COVID-19) 发烧的儿童应在选择性手术前至少等待4周. 等待更长时间显著降低了手术期间手术内氧气脱的风险.
科学领域:
- 儿科麻醉学 儿科麻醉学
- 传染性疾病 传染性疾病
- 外科手术的结果
背景情况:
- 患有SARS-CoV-2感染的儿童的发烧与手术期间氧气和风险增加有关.
- 儿科SARS-CoV-2患者发烧缓解后手术的最佳时间尚不清楚.
研究的目的:
- 确定SARS-CoV-2感染和发烧后儿童选择性手术的最佳时间.
- 检查发烧缓解后的时间与手术期间氧气脱的发生率之间的关系.
主要方法:
- 对患有SARS-CoV-2感染的儿科患者进行前性队列研究,接受手术后发烧解决 (2023年3月至8月).
- 主要结局:手术中氧气脱的发生率.
- 逻辑回归分析按从发烧缓解到手术的时间间隔分层 (0-2,3-4,5-6,7-8周和≥3个月).
主要成果:
- 整体手术期间氧气脱率为7.96%.
- 发烧后0至2周 (18.3%) 和3至4周 (11.5%) 中观察到的脱率最高.
- 与≥3个月相比,发烧解消后持续4周的脱度风险显著更高 (aOR为5.56为0-2周,aOR为3.31为3-4周).
- 年轻的年龄,较高的BMI,异常的胸部放射和持续的症状是脱的危险因素.
结论:
- 在有SARS-CoV-2感染史的儿科患者中,选择性手术应推迟至发烧消失后至少4周.
- 将手术推迟到发烧后4周后的时间,可以最大限度地降低手术期间氧气不和的风险.
- 进一步的研究可能会探索特定的症状学或基于生物标志物的早期手术资格标准.
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