与JIA相关的胰腺炎的长期结果:系统性审查和元分析
Laura Scagnellato1, Giacomo Cozzi1, Mariagrazia Lorenzin1
1Rheumatology Unit, Department of Medicine-DIMED, Padova University Hospital, Padova, Italy.
RMD open
|November 28, 2025
概括
青春期异常性关节炎相关性脑膜炎 (JIAU) 可以导致长期的视力问题到成年. 超过10%的JIAU患者经历严重的视力障碍,即使使用现代治疗.
科学领域:
- 眼科医生 眼科 眼科
- 类风湿病学 类风湿病学
- 儿科 儿科 儿科
背景情况:
- 青少年异常性关节炎相关性脑膜炎 (JIAU) 是一种从童年开始的慢性炎症性眼部疾病.
- 它可以导致患者一生中逐渐的眼损伤和视力丧失.
- 了解成年期的长期结果对于管理JIAU至关重要.
研究的目的:
- 系统地审查和综合有关JIAU成人长期眼部并发症的证据.
- 专注于过去20年内发表的研究,以获取最近的数据.
- 估计这个人群中各种眼部损伤的累积发病率.
主要方法:
- 一个系统的审查和对JIAU的人类研究的元分析.
- 纳入标准:具有≥5年随访时间或成人参与者 (≥18岁) 的研究,发表于2000年以后.
- 使用纽卡斯尔-太华尺度评估研究质量;使用R包计算的聚合估计 (PE).
主要成果:
- 包括22项研究 (2208例);研究质量不同 (好,公平,差).
- 观察到很高的异质性,但元分析结果是强大的.
- 严重视力障碍的综合发病率在18岁时~16.6%;白内障最常见 (PE 44.3%).
结论:
- JIAU的眼部并发症经常持续到成年,影响长期视力.
- 严重的视力损伤影响超过10%的成年人与JIAU,即使有生物疗法.
- 白内障,绿内障和眼是显著的长期担忧.
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