在阿根廷:关于患病率和临床结果的多中心研究
Pablo Corral1, Maria Gabriela Matta2, Nicolás F Renna3
1FASTA University, Pharmacology and Research Department, Mar del Plata, Buenos Aires, Argentina.
Atherosclerosis
|November 28, 2025
概括
升高的脂蛋白 (a) [Lp (a) ]影响了近三分之一的阿根廷人,并显著增加了心血管风险. 在未服用他类药物的患者中,这种风险甚至更高,这强调了Lp (a) 作为剩余风险评估的关键标志物.
科学领域:
- 心脏病学 心脏病学
- 遗传学 遗传学 是一个
- 流行病学 流行病学
背景情况:
- 脂蛋白 (Lp) 是一种基因决定的心血管风险因素.
- 关于拉丁美洲Lp (a) 患病率和影响的数据有限.
- 在GAELp (a) 登记处解决了阿根廷的知识差距.
研究的目的:
- 评估阿根廷升高Lp (a) 的患病率.
- 评估升高的Lp(a) 与心血管结果之间的关联.
- 探索Lp (a) 在未服用过他类药物的个体中的作用.
主要方法:
- 一个大型的多中心注册 (GAELp(a)) 3000阿根廷成年人.
- 标准化Lp (a) 试验的高度定义为>50 mg/dL或>125 nmol/L.
- 后勤回归分析以评估与主要不良心血管事件 (MACE) 的关联.
主要成果:
- 在31.4%的参与者中发现了升高的Lp (a),与家族病史和亚临床动脉样硬化有关.
- 患有升高Lp的患者有较高的冠状动脉疾病,外周动脉疾病和MACE的发病率.
- 升高的Lp (a) 独立预测MACE,在以前没有服用他类药物的人群中具有更强的关联.
结论:
- 升高的Lp (a) 在阿根廷很常见,与心血管疾病和事件有很强的联系.
- Lp (a) 是残留心血管风险的显著标志物,特别是在以前没有服用他类药物的患者中.
- 建议在高ASCVD负担地区进行常规Lp(a) 测量,以评估心血管风险.
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