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探索慢性d-cycloserine给药对GluN2亚单元的表达和在thalamocortical通路中的三方突触传播的影响

Motohiro Okada¹, Ruri Okubo¹, Nobutomo Yamamoto²

¹Department of Neuropsychiatry, Division of Neuroscience, Graduate School of Medicine, Mie University, Tsu, Mie, Japan.

British journal of pharmacology

|November 28, 2025

概括

通过调节NMDA受体子单元和神经递质释放,D-环素会对精神分裂症的负面症状产生影响. 它的有效性取决于GluN2C的剂量依赖激活和非激活,突出显示治疗窗口狭窄.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.
精神病学是一个精神病学.

背景情况:

作为NMDA受体协激剂的D-环素显示出治疗精神分裂症负面症状的潜力.
它的治疗机制和狭窄的治疗窗口仍然不清楚.

研究的目的:

研究d-环素对NMDA受体子单元 (GluN2A,GluN2B,GluN2C) 的剂量依赖作用.
为了阐明d-cycloserine对l-glutamate,d-serine以及大脑中的GABA传播的影响.
在大鼠模型中探索d-cycloserine的作用与其治疗疗效之间的关系.

主要方法:

在成年雄性大鼠中长期使用d-cycloserine.
微透析和毛细血管免疫血栓检测以评估GluN2亚单元表达和神经递质释放.
评估糖糖偏好以模拟无和评估治疗效果.

主要成果:

根据d-cycloserine的剂量,增加了星质l-glutamate/d-serine和神经元GABA释放,GluN2C表现出更高的内在活性.
慢性服用降低了GluN2C,GluN2B和GluN2A的表达,减弱了d-cycloserine诱导的神经递质释放.
低剂量慢性d-cycloserine (2 mg·kg−1) 恢复了糖糖偏好,而高剂量则没有.

结论:

在精神分裂症中,D-cycloserine的疗效可能涉及剂量依赖的GluN2C调制,导致激活或非激活.
这项研究揭示了d-cycloserine的狭窄治疗窗口,与GluN2A和GluN2C的差异性影响有关.
这些发现为d-cycloserine的作用及其在治疗负性精神分裂症症状方面的局限性提供了机制性的见解.

关键词:

这是一种d-cycloserine.这种NMDA/谷氨酸酸受体是NMDA/谷氨酸受体.抑郁抑郁症抑郁症抑郁症抑郁症病理生理学病理生理学精神分裂症是一种精神分裂症.泰拉姆斯 (thalamus) 是一个神经系统.

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