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肌素A-E的集体不对称总合成

Yichen Liu¹, Yanghui Ou², Vincent Chang¹

¹Department of Chemistry, The Hong Kong University of Science and Technology, Clearwater Bay, Kowloon, Hong Kong, China.

The Journal of organic chemistry

|November 28, 2025

概括

这项研究介绍了首次对罕见的细胞毒性化合物musellarins D和E的总合成. 一项新的策略纠正了它们的结构,并扩大了对相关 musellarins 的合成获取.

科学领域:

有机化学有机化学
自然产品的合成自然产品的合成

背景情况:

肌蛋白是罕见的细胞毒性二甲基类天然产品.
墨塞拉林D和E,具有cis-fused二胺环,是合成未开发的.

研究的目的:

为了实现穆斯拉林A-E.E.的集体总合成.
建立第一个合成途径,使得D和E. musellarins成为第一个合成途径.
为了纠正 musellarins D 和 E 的立体化学分配.

主要方法:

基于阿克马托维奇重组的合成策略的开发.
阿克马托维奇重组产品与酸的催化 arylation.

主要成果:

成功完成了穆斯拉林A-E.E.的总合成.
第一次合成 musellarins D 和 E,证实了一个 cis-fused dihydropyran 基因.
对D和E. Mussellarins的C10b配置进行了校正.
获得跨和 cis-dihydropyran 异构体.

结论:

开发的战略提供了对含有cis和trans-dihydropyran的musslarins的获取.
这项工作纠正了 Mussellarins D 和 E 的立体化学.
合成为探索这些化合物的生物活动开辟了道路.

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