组织工程中的基因治疗策略:再生疗法的进展和应用
Hasan Akbaba1, Lucy Homer2, Thi Bao Tram Tran2
1Institute of Materials Science, Polymer Program, University of Connecticut, Storrs, CT 06269, USA; Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Ege University, Izmir, 35100, Turkey.
Trends in biotechnology
|November 28, 2025
概括
基因治疗为组织再生提供了新的希望,克服了传统治疗的局限性. 这篇评论探讨了CRISPR基因编辑和3D生物打印等未来组织工程的进步.
科学领域:
- 再生医学是一种再生医学.
- 分子生物学分子生物学
- 生物技术是生物技术.
背景情况:
- 传统的组织再生治疗方法存在局限性.
- 基因疗法是一个有前途的替代策略.
- 分子生物学和遗传学正在取得重大进展.
研究的目的:
- 提供基因疗法在组织再生中的应用概述.
- 突出该领域最近的进展和未来的方向.
- 为了解决有关组织工程基因疗法的当前文献的空白.
主要方法:
- 关于用于组织再生的基因疗法的当前文献的综述.
- 检查聚类有规律间隔的短时间palindromic重复 (CRISPR) 基因编辑的发展.
- 对3D生物打印和用于组织工程的基因传递系统的进展进行分析.
主要成果:
- 基因疗法在组织再生应用中显示出显著的潜力.
- 案例研究和临床试验证明了成功的应用.
- 像CRISPR和3D生物打印等新兴技术正在推动这一领域的发展.
结论:
- 基因疗法是组织再生的强大工具.
- 未来的方向包括基于基因的个性化方法.
- 克服挑战是实现基因治疗在组织工程中的全部潜力的关键.
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