通过FXR介导的抗原特异性CD8+ T细胞在肝脏内胆管癌中增强抗瘤免疫力

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Shanshan Liu1, Zhixing Liang2, Lisi Zhu1

  • 1Guangdong Provincial Key Laboratory of Immune Regulation and Immunotherapy, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China.

Journal for immunotherapy of cancer
|November 28, 2025
PubMed
概括

法尔内索伊德X受体 (FXR) 驱动CD8+T细胞在肝脏内胆管癌 (ICC) 中的耗尽. 用ursodeoxycholic acid (UDCA) 抑制FXR可以恢复T细胞功能,并增强ICC的免疫疗法.

关键词:
组合疗法是一种联合疗法.阴茎癌 阴茎癌是一种癌症.的T-淋巴细胞.瘤透淋巴细胞 - - TIL瘤微环境 - - 瘤微环境

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