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维生素C输液在术后机械通风新生儿感染败血症中的作用:一项随机对照试验
Asmaa Mahmoud Elmesiry1, Mai Rabie Elsheikh2, Khalid Mohamed Elshimy3
1Pediatrics and Neonatology Department, Faculty of Medicine, Tanta University, Alestad Street, Tanta, 31527, Al Gharbia, Egypt. asmaa.elmesery@med.tanta.edu.eg.
European journal of pediatrics
|November 28, 2025
概括
静脉注射的维生素C改善了呼吸功能,并减少了在手术后败血症新生儿的机械通风持续时间. 然而,它并没有显著影响死亡率或住院时间.
科学领域:
- 新生儿医学 新生儿医学
- 关键的护理关键的护理
- 药理学 药理学是指药理学的学科.
背景情况:
- 新生儿败血症是新生儿重症监护室 (NICU) 中死亡和发病的主要原因.
- 维生素C正在被探索为治疗败血症的治疗剂,因为它在免疫反应和炎症控制中的多方面的作用.
研究的目的:
- 评估静脉注射维生素C在改善术后败血症,机械通风 (MV) 新生儿的呼吸系统参数和临床结果方面的疗效.
主要方法:
- 一个双盲随机受控试验,涉及50名满期新生儿,在手术后患有败血症,需要机械通风.
- 参与者接受了安慰剂的标准护理或注射维生素C的标准护理 (0.5g/kg的充满剂量,然后6小时的0.5g/kg/h,为7-10天).
主要成果:
- 维生素C组在不同时间点显示出明显较低的呼吸速率,峰值吸气压力和FiO2需求.
- 在维生素C组观察到,机械通风的持续时间缩短 (4.44天而不是5.64天),对内支持的需求减少 (40%而不是76%).
- 两组之间没有发现死亡率或住院/NICU停留时间的显著差异.
结论:
- 静脉注射维生素C证明了在改善呼吸系统参数和减少在术后败血症新生儿机械通风和内支持的需要方面具有显著的益处.
- 虽然维生素C对特定结果有效,但在这个队列中,维生素C并没有显著改变整体死亡率或住院时间.
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