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改善2型糖尿病的药物坚持:改善临床和经济结果的策略
Patrick J Highton1,2, Mark P Funnell3,4, Pankaj Gupta4,5
1Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK. ph204@leicester.ac.uk.
Diabetologia
|November 28, 2025
概括
在2型糖尿病中不服药会影响血糖控制,增加并发症风险. 个性化,多方面的干预措施是最有效的改善坚持和患者的结果.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 药物坚持对于管理2型糖尿病 (T2DM) 和预防并发症至关重要.
- 不遵守是广泛存在的问题,全球约有38%的T2DM患者受到影响,受各种患者,社会经济和医疗保健因素的影响.
研究的目的:
- 审查T2DM中药物不服药的患病率,风险因素和后果.
- 评估旨在改善这一群体的药物坚持的干预措施.
主要方法:
- 对T2DM药物坚持的现有证据的系统审查.
- 分析风险因素,临床和经济结果以及干预的有效性.
- 探索各种评估方法,从自我报告到客观的生物化学测试.
主要成果:
- 不遵守与HbA1c升高,微/宏血管并发症风险增加,住院治疗,死亡率和医疗保健成本增加有关.
- 药剂师主导的护理和固定剂量组合疗法显示出希望,而基于技术和激励的策略产生混合的结果.
- 共享决策和行为干预措施 (例如,CBT) 可能有利于患有并发症的患者.
结论:
- 随着时间的推移,持续的多方面的,个性化的干预措施是最有效的改善T2DM药物坚持.
- 未来的研究应该专注于可扩展,公平,个性化和多元组件干预措施,用于不同的医疗保健环境.
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