抑制TBK1/IKKε介导的RIPK1酸化使瘤对免疫细胞杀死产生敏感性

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Updated: Jan 10, 2026

Tyramide Signal Amplification for the Immunofluorescent Staining of ZBP1-Dependent Phosphorylation of RIPK3 and MLKL After HSV-1 Infection in Human Cells
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Tyramide Signal Amplification for the Immunofluorescent Staining of ZBP1-Dependent Phosphorylation of RIPK3 and MLKL After HSV-1 Infection in Human Cells

Published on: October 20, 2022

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Anastasia Piskopou1,2, David W Vredevoogd3, Xiangjun Kong3

  • 1Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, The Netherlands.

Cell death discovery
|November 28, 2025
PubMed
概括

瘤细胞通过阻断生存信号来抵抗免疫攻击. 阻止这种信号,涉及RIPK1,TBK1和IKKε,增强T细胞和NK细胞的杀死,改善癌症免疫疗法.

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